TAF II p68 Rabbit Polyclonal Antibody

This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012], disease:A chromosomal aberration involving TAF15/TAF2N is found in a form of extraskeletal myxoid chondrosarcomas (EMC) . Translocation t (9;17) (q22; q11) with NR4A3., function:RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II) ., PTM:Arg-206 is dimethylated, probably to asymmetric dimethylarginine., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the RRM TET family., similarity:Contains 1 RanBP2-type zinc finger., similarity:Contains 1 RRM (RNA recognition motif) domain., subunit:Belongs to the RNA polymerase II (Pol II) transcriptional multiprotein complex, together with the TATA-binding protein (TBP) and other TBP-associated factors (TAF (II) s) . Binds SF1., tissue specificity:Ubiquitous. Observed in all fetal and adult tissues.

TAF15; RBP56; TAF2N; TATA-binding protein-associated factor 2N; 68 kDa TATA-binding protein-associated factor; TAF (II) 68; TAFII68; RNA-binding protein 56