Neuralized-2 Rabbit Polyclonal Antibody

This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013], domain:The SOCS domain mediates the interaction with TCEB1 and TCEB2, while the NHR domain may be involved in ubiquitination substrate binding., function:Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma., pathway:Protein modification; protein ubiquitination., similarity:Contains 1 NHR (neuralized homology repeat) domain., similarity:Contains 1 SOCS box domain., subunit:Probable component the ECS (NEURL2) E3 ubiquitin-protein ligase complex consisting of TCEB2/Elongin B, TCEB1/Elongin C, CUL5, RBX1 and NEURL2. Interacts with CTNNB1., tissue specificity:Expressed specifically in skeletal and cardiac muscles.