MINK1 Rabbit Polyclonal Antibody

This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016], catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., function:Serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in the development of the brain., similarity:Belongs to the protein kinase superfamily., similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily., similarity:Contains 1 CNH domain., similarity:Contains 1 protein kinase domain., tissue specificity:Expressed in the brain, isoform 2 is more abundant than isoform 1.

MINK1; B55; MAP4K6; MINK; YSK2; ZC3; Misshapen-like kinase 1; GCK family kinase MiNK; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6; Misshapen/NIK-related kinase; Mitogen-activated protein kinase kinase kinase kinase 6