MALT1 Rabbit Polyclonal Antibody

This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008], disease:A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma) . Translocation t (11;18) (q21; q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma., function:Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL-10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion., similarity:Belongs to the peptidase C14B family., similarity:Contains 1 death domain., similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains., subcellular location:Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10., subunit:Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6., tissue specificity:Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.