GAK Rabbit Polyclonal Antibody

Cyclin G associated kinase (GAK) Homo sapiens In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015], catalytic activity:ATP + a protein = ADP + a phosphoprotein., function:Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1., similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family., similarity:Contains 1 C2 tensin-type domain., similarity:Contains 1 J domain., similarity:Contains 1 phosphatase tensin-type domain., similarity:Contains 1 protein kinase domain., subcellular location:Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focals adhesions., tissue specificity:Ubiquitous. Highest in testis.