APBA2BP Rabbit Polyclonal Antibody

The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], alternative products:Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms, function:Inhibits the interaction of APBA2 with beta-amyloid precursor protein (APP), and hence allows formation of beta-amyloid., PTM:Phosphorylated by NEK2., similarity:Contains 1 ABM domain., similarity:Contains 1 EF-hand domain., subunit:Interacts with the N-terminal domain of APBA2. Interacts with NEK2., tissue specificity:Strongly expressed in heart and skeletal muscle, moderately in brain and pancreas.

NECAB3; APBA2BP; NIP1; SYTIP2; XB51; N-terminal EF-hand calcium-binding protein 3; Amyloid beta A4 protein-binding family A member 2-binding protein; Nek2-interacting protein 1; Neuronal calcium-binding protein 3; X11L-binding protein 51