AF-10 Rabbit Polyclonal Antibody

Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 (MLLT10) Homo sapiens This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010], disease:A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t (10;11) (p12; q23) with MLL/HRX. The result is a rogue activator protein., disease:A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t (10;11) (p13; q14) with PICALM., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Contains 2 PHD-type zinc fingers., tissue specificity:Expressed abundantly in testis.