ADAMTS-18 Rabbit Polyclonal Antibody

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may regulate hemostatic balance and function as a tumor suppressor. Mutations in this gene may be associated with microcornea, myopic chorioretinal atrophy, and telecanthus (MMCAT) and cone-rod dystrophy in human patients. [provided by RefSeq, May 2016], cofactor:Binds 1 zinc ion per subunit., domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme., PTM:The precursor is cleaved by a furin endopeptidase., similarity:Contains 1 disintegrin domain., similarity:Contains 1 peptidase M12B domain., similarity:Contains 1 PLAC domain., similarity:Contains 5 TSP type-1 domains., tissue specificity:Expressed in fetal lung, liver, and kidney and in adult brain, prostate, submaxillary gland, and endothelium.