TSSK 4 Rabbit Polyclonal Antibody

This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010], catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., enzyme regulation:Activated by phosphorylation on Thr-197, potentially by autophosphorylation., function:May be involved in a signaling pathway during male germ cell development or mature sperm function (By similarity) . Phosphorylates CREB1 on Ser-133 and stimulates downstream signaling., PTM:Autophosphorylated (By similarity) . Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family., similarity:Contains 1 protein kinase domain., tissue specificity:Expressed only in the testis.

TSSK4; C14orf20; STK22E; TSSK5; Testis-specific serine/threonine-protein kinase 4; TSK-4; TSSK-4; Testis-specific kinase 4; Serine/threonine-protein kinase 22E