ARHGEF10 Rabbit Polyclonal Antibody
Product Specifications
Background
This gene encodes a Rho guanine nucleotide exchange factor (GEF) . Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV) . Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015], disease:Defects in ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV) [MIM:608236]. Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant., function:May play a role in developmental myelination of peripheral nerves., sequence caution:Cloning artifact., sequence caution:Translated as Lys., similarity:Contains 1 DH (DBL-homology) domain.
Product Name Alternative
ARHGEF10; KIAA0294; Rho guanine nucleotide exchange factor 10
Gene Name
ARHGEF10
Gene ID
9639
Swiss Prot
O15013
Host
Rabbit
Reactivity
Human, Monkey
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, ELISA
Field of Research
Regulation of Actin Dynamics; AMPK
Purification
Affinity purification
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, ICC/IF 1:50-1:200, ELISA 1:10000-1:20000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
152kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Product Datasheet
https://assets.enkilife.com/files/antibody/APRab07127_Enkilife_EN.pdf
Isotype
IgG
Available Sizes
Curated Selection
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