REP-2 Rabbit Polyclonal Antibody

The product of the CHML gene supports geranylgeranylation of most Rab proteins and may substitute for REP-1 in tissues other than retina. CHML is localized close to the gene for Usher syndrome type II. [provided by RefSeq, Jul 2008], function:Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than REP-1 in supporting prenylation of Rab3 family., miscellaneous:Substitutes for REP-1 thereby preventing widespread tissue abnormalities in patients with choroideremia who lack REP-1., similarity:Belongs to the Rab GDI family., subunit:Monomer. Interacts with Rab and Rab GGTase.