PSCA Rabbit Polyclonal Antibody

This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010], function:May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro., induction:Down-regulated in gastric cancer cells., polymorphism:Genetic variations in PSCA may influence susceptibility to diffuse-type gastric cancer., similarity:Contains 1 UPAR/Ly6 domain., tissue specificity:Highly expressed in prostate (basal, secretory and neuroendocrine epithelium cells) . Also found in bladder (transitional epithelium), placenta (trophoblasts), stomach (neuroendocrine cells), colon (neuroendocrine cells) and kidney (collecting ducts) . Overexpressed in prostate cancers and expression is correlated with tumor stage, grade and androgen-independence. Highly expressed in prostate cancer bone metastases. Expressed in gastric epithelial cells, mainly in the isthmus (at protein level) . Not detected in normal intestinal epithelium (at protein level) .