MRP7 Rabbit Polyclonal Antibody

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White) . This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010], function:ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion., similarity:Belongs to the ABC transporter family., similarity:Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily., similarity:Contains 2 ABC transmembrane type-1 domains., similarity:Contains 2 ABC transporter domains., tissue specificity:Isoform 1 is specifically expressed in spleen. Isoform 2 is more widely expressed.