N/H/K-Ras Rabbit Polyclonal Antibody

This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011], disease:Defects in NRAS are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia., disease:Mutations which change AA 12, 13 or 61 activate the potential of Ras to transform cultured cells and are implicated in a variety of human tumors., enzyme regulation:Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP) ., function:Ras proteins bind GDP/GTP and possess intrinsic GTPase activity., online information:NRAS mutation db, online information:RAS proteins entry, PTM:Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi., similarity:Belongs to the small GTPase superfamily. Ras family., subcellular location:Shuttles between the plasma membrane and the Golgi apparatus.

NRAS; HRAS1; GTPase NRas; Transforming protein N-Ras; HRAS; HRAS1; GTPase HRas; H-Ras-1; Ha-Ras; Transforming protein p21; c-H-ras; p21ras; KRAS; KRAS2; RASK2; GTPase KRas; K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras

MAPK_ERK_Growth; MAPK_G_Protein; ErbB_HER; Chemokine; Axon guidance; VEGF; Tight junction; Gap junction; Natural killer cell mediated cytotoxicity; T_Cell_Receptor; B_Cell_Antigen; Fc epsilon RI; Long-term potentiation; Neurotrophin; Long-term depression; Regulates Actin and Cytoskeleton; Insulin_Receptor; GnRH; Melanogenesis; Pathways in cancer; Renal cell carcinoma; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer