SR-4 Rabbit Polyclonal Antibody

This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine) . The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010], alternative products:Additional isoforms seem to exist, function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase., similarity:Belongs to the G-protein coupled receptor 1 family., subcellular location:Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli., subunit:Isoform 5-HT4 (A) interacts with MAGI2, MPP3, SLC9A3R1 and SNX27 isoforms 1 and 2. Isoform 5-HT4 (E) interacts with INADL, NOS1 and SEC23A. Isoform 5-HT4 (A) forms a complex including SLC9A3R1 and EZR., tissue specificity:Isoform 5-HT4 (A) is expressed in ileum, brain, and atrium, but not in the ventricle.