C/EBP ε (phospho Thr74) Rabbit Polyclonal Antibody

The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008], function:C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers., online information:CEBPE mutation db, PTM:Phosphorylated., similarity:Belongs to the bZIP family. C/EBP subfamily., similarity:Contains 1 bZIP domain., subunit:Binds DNA as a dimer and can form stable heterodimers with C/EBP delta., tissue specificity:Strongest expression occurs in promyelocyte and late-myeloblast-like cell lines.