IRF-4 Rabbit Polyclonal Antibody

The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t (6;14) (p25; q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010], disease:A chromosomal aberration involving IRF4 may be a cause of multiple myeloma [MIM:254500]. Translocation t (6;14) (p25; q32) with the IgH locus., function:Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells., induction:Not induced by interferons., similarity:Belongs to the IRF family., similarity:Contains 1 tryptophan pentad repeat DNA-binding domain., subunit:Interacts with SPIB and DEF6., tissue specificity:Lymphoid cells.