TACC1 Rabbit Polyclonal Antibody

This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009], alternative products:Additional isoforms seem to exist, developmental stage:Expressed at high level during early embryogenesis., function:Likely involved in the processes that promote cell division prior to the formation of differentiated tissues., miscellaneous:Down-regulated in a subset of cases of breast cancer., PTM:Isoform 1 is heavily phosphorylated; isoform 6 is not. Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the TACC family., similarity:Contains 2 SPAZ (Ser/Pro-rich AZU-1) domains., subcellular location:Nucleus during interphase. Weakly concentrated at centrosomes during mitosis., subunit:Interacts with KIAA0097/CH-TOG and with the oncogenic transcription factor YEATS4. Interacts with the Aurora kinases A and B (STK6 and AURKB) . Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF., tissue specificity:Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues.