HSP105 Rabbit Polyclonal Antibody

Function:Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities., PTM:Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity., similarity:Belongs to the heat shock protein 70 family., subunit:Interacts with HSPA8/HSC70., tissue specificity:Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells., function:Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities., PTM:Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity., similarity:Belongs to the heat shock protein 70 family., subunit:Interacts with HSPA8/HSC70., tissue specificity:Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.