SphK2 Rabbit Polyclonal Antibody

This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011], alternative products:Experimental confirmation may be lacking for some isoforms, catalytic activity:ATP + sphinganine = ADP + sphinganine 1-phosphate., catalytic activity:ATP + sphingosine = ADP + sphingosine 1-phosphate., cofactor:Magnesium., function:Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra-and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine., similarity:Contains 1 DAGKc domain.