KV3.1 Rabbit Polyclonal Antibody

This gene encodes a member of a family of integral membrane proteins that mediate the voltage-dependent potassium ion permeability of excitable membranes. Alternative splicing is thought to result in two transcript variants encoding isoforms that differ at their C-termini. These isoforms have had conflicting names in the literature: the longer isoform has been called both "b" and "alpha", while the shorter isoform has been called both "a" and "beta" (PMIDs 1432046, 12091563) . [provided by RefSeq, Oct 2014], domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position., domain:The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments., function:Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient., similarity:Belongs to the potassium channel family. C (Shaw) subfamily., subunit:Heteromultimer with KCNG3, KCNG4 and KCNV2.

KCNC1; Potassium voltage-gated channel subfamily C member 1; NGK2; Voltage-gated potassium channel subunit Kv3.1; Voltage-gated potassium channel subunit Kv4