MYSM1 Rabbit Polyclonal Antibody
Product Specifications
Background
Catalytic activity:Ubiquitin C-terminal thioester + H (2) O = ubiquitin + a thiol., domain:Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA., function:Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR) -induced gene activation., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the peptidase M67A family. MYSM1 subfamily., similarity:Contains 1 MPN (JAB/Mov34) domain., similarity:Contains 1 SANT domain., similarity:Contains 1 SWIRM domain., subunit:Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Binds histones., catalytic activity:Ubiquitin C-terminal thioester + H (2) O = ubiquitin + a thiol., domain:Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA., function:Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR) -induced gene activation., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the peptidase M67A family. MYSM1 subfamily., similarity:Contains 1 MPN (JAB/Mov34) domain., similarity:Contains 1 SANT domain., similarity:Contains 1 SWIRM domain., subunit:Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Binds histones.
Product Name Alternative
MYSM1; KIAA1915; Histone H2A deubiquitinase MYSM1; 2A-DUB; Myb-like; SWIRM and MPN domain-containing protein 1
Gene Name
MYSM1
Gene ID
114803
Swiss Prot
Q5VVJ2
Host
Rabbit
Reactivity
Human, Rat, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, ELISA
Purification
Affinity purification
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, ICC/IF 1:50-1:200, ELISA 1:20000-1:40000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
95kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
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