MYSM1 Rabbit Polyclonal Antibody

Catalytic activity:Ubiquitin C-terminal thioester + H (2) O = ubiquitin + a thiol., domain:Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA., function:Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR) -induced gene activation., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the peptidase M67A family. MYSM1 subfamily., similarity:Contains 1 MPN (JAB/Mov34) domain., similarity:Contains 1 SANT domain., similarity:Contains 1 SWIRM domain., subunit:Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Binds histones., catalytic activity:Ubiquitin C-terminal thioester + H (2) O = ubiquitin + a thiol., domain:Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA., function:Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR) -induced gene activation., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the peptidase M67A family. MYSM1 subfamily., similarity:Contains 1 MPN (JAB/Mov34) domain., similarity:Contains 1 SANT domain., similarity:Contains 1 SWIRM domain., subunit:Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Binds histones.