CEP170 Rabbit Polyclonal Antibody

Centrosomal protein 170 (CEP170) Homo sapiens The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008], function:Plays a role in microtubule organization., PTM:Phosphorylated; probably by PLK1. Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the CEP170 family., similarity:Contains 1 FHA domain., subcellular location:Associated with the mature mother centriole. Associated with spindle microtubules during mitosis., subunit:Interacts with PLK1.