EEF2K (phospho Ser366) Rabbit Polyclonal Antibody

This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008], catalytic activity:ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate., enzyme regulation:Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent., function:Phosphorylates eukaryotic elongation factor-2. Binds calmodulin., similarity:Belongs to the protein kinase superfamily. Alpha-type protein kinase family., similarity:Contains 1 alpha-type protein kinase domain., subunit:Monomer or homodimer .