Synaptotagmin 1/2 (phospho Thr202/199) Rabbit Polyclonal Antibody

The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca (2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]) .[supplied by OMIM, Jul 2010], cofactor:Binds 3 calcium ions per subunit. The ions are bound to the C2 domains., domain:The first C2 domain mediates Ca (2+) -dependent phospholipid binding., domain:The second C2 domain mediates interaction with SV2A and STN2., function:May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca (2+) -dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca (2+) -independent manner; these are neurexins, syntaxin and AP2., similarity:Belongs to the synaptotagmin family., similarity:Contains 2 C2 domains., subcellular location:Synaptic vesicles and chromaffin granules., subunit:Homotetramer (Probable) . Interacts with SCAMP5, STN2, SV2A, SV2B, SV2C and RIMS1. Forms a complex with SV2B, syntaxin 1 and SNAP25.