PKD2 (phospho Ser876) Rabbit Polyclonal Antibody

The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008], catalytic activity:ATP + a protein = ADP + a phosphoprotein., enzyme regulation:Activated by diacylglycerol and phorbol esters., function:Calcium-independent, phospholipid-dependent, serine- and threonine-specific protein kinase., PTM:Autophosphorylated. Phorbol esters stimulates autophosphorylation. Phosphorylation of Ser-876 correlates with the activation status of the kinase., similarity:Belongs to the protein kinase superfamily., similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily., similarity:Contains 1 PH domain., similarity:Contains 1 protein kinase domain., similarity:Contains 2 phorbol-ester/DAG-type zinc fingers., tissue specificity:Widely expressed.