MYLIP Rabbit Polyclonal Antibody

The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. [provided by RefSeq, Jul 2008], developmental stage:Expressed in fetal tissues and higher levels were detected in placenta and fetal lung., domain:The RING domain mediates ubiquitination and the neurite outgrowth inhibitory activity., function:E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC) . Stable or transient overexpression of MIR induces proteasomal degradation of MRLC inhibiting neurite outgrowth in presence of NGF. MIR counteracts the stabilization of MRLC by MIR-interacting saposin-like protein (MSAP/TMEM4) and reduces MSAP-stimulated neurite outgrowth., pathway:Protein modification; protein ubiquitination., PTM:Autoubiquitinated., similarity:Contains 1 FERM domain., similarity:Contains 1 RING-type zinc finger., subunit:Interacts with myosin regulatory light chain (MRLC) and TMEM4., tissue specificity:Ubiquitously expressed.

MYLIP; BZF1; IDOL; BM-023; PP5242; E3 ubiquitin-protein ligase MYLIP; Inducible degrader of the LDL-receptor; Idol; Myosin regulatory light chain interacting protein; MIR