Cdc20 Rabbit Polyclonal Antibody

CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008], developmental stage:Synthesis is initiated at G1/S, protein level peaks in M phase and protein is abruptly degraded at M/G1 transition., function:Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1. In metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates., pathway:Protein modification; protein ubiquitination., PTM:Phosphorylated during mitosis, probably by maturation promoting factor (MPF) ., PTM:Ubiquitinated and degraded by the proteasome during spindle assembly checkpoint., similarity:Belongs to the WD repeat CDC20/Fizzy family., similarity:Contains 7 WD repeats., subunit:Found in a complex with CDC20, CDC27, SPATC1 and TUBG1. Interacts with SPATC1 (By similarity) . Interacts with MAD2L1 and BUB1B. The phosphorylated form interacts with APC/C.