Cdc25C (phospho Ser216) Rabbit Polyclonal Antibody

Cell division cycle 25C (CDC25C) Homo sapiens This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Dec 2015], catalytic activity:Protein tyrosine phosphate + H (2) O = protein tyrosine + phosphate., developmental stage:Expressed predominantly in G2 phase., function:Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity., PTM:Phosphorylated by CHK1 on Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase., similarity:Belongs to the MPI phosphatase family., similarity:Contains 1 rhodanese domain., subunit:Interacts with HIV-1 Vpr, thereby inactivating CDC25C phosphatase activity.