Pdcd-4 (phospho Ser457) Rabbit Polyclonal Antibody

This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010], caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data., disease:Loss of expression correlated with tumor progression of lung and colon carcinoma., domain:Binds EIF4A1 via the MA3 domains., function:Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Inhibits the helicase activity of EIF4A and cap-dependent translation. Binds RNA., induction:IL2 stimulation inhibits expression, while IL12 increases expression., sequence caution:Contaminating sequence. Potential poly-A sequence., similarity:Belongs to the PDCD4 family., similarity:Contains 2 MI domains., subcellular location:Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions. Exported from the nucleus in the absence of serum., subunit:Interacts with EIF4A1 and EIF4A2., tissue specificity:Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland.