IL-3Rβ (phospho Tyr593) Rabbit Polyclonal Antibody

The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP) . [provided by RefSeq, Jul 2008], disease:Defects in CSF2RB are a cause of congenital pulmonary alveolar proteinosis (PAP) [MIM:265120]. PAP is an autosomal recessive fatal respiratory disease., domain:The box 1 motif is required for JAK interaction and/or activation., domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding., function:High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor., similarity:Belongs to the type I cytokine receptor family. Type 4 subfamily., similarity:Contains 2 fibronectin type-III domains., subunit:Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors.