CHSY1 Rabbit Polyclonal Antibody
Product Specifications
Background
This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. These enzymes possess dual glucuronyltransferase and galactosaminyltransferase activity and play critical roles in the biosynthesis of chondroitin sulfate, a glycosaminoglycan involved in many biological processes including cell proliferation and morphogenesis. Decreased expression of this gene may play a role in colorectal cancer, and mutations in this gene are a cause of temtamy preaxial brachydactyly syndrome. [provided by RefSeq, Dec 2011], catalytic activity:UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl- (1->4) -beta-D-glucuronosyl-proteoglycan = UDP + beta-D-glucuronosyl- (1->3) -N-acetyl-beta-D-galactosaminyl- (1->4) -beta-D-glucuronosyl-proteoglycan., catalytic activity:UDP-N-acetyl-D-galactosamine + beta-D-glucuronosyl- (1->3) -N-acetyl-beta-D-galactosaminyl-proteoglycan = UDP + N-acetyl-beta-D-galactosaminyl- (1->4) -beta-D-glucuronosyl- (1->3) -N-acetyl-beta-D-galactosaminyl-proteoglycan., cofactor:Divalent cations. Highest activities are measured with cobalt, manganese and cadmium., function:Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer., online information:Chondroitin sulfate synthase 1, online information:GlycoGene database, similarity:Belongs to the chondroitin N-acetylgalactosaminyltransferase family., subunit:Binds CHPF., tissue specificity:Ubiquitous, with the highest levels in placenta. Detected at low levels in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, adrenal gland, mammary gland, stomach, small intestine, lung and peripheral blood leukocytes.
Product Name Alternative
CHSY1; CHSY; CSS1; KIAA0990; Chondroitin sulfate synthase 1; Chondroitin glucuronyltransferase 1; Chondroitin synthase 1; ChSy-1; Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1; N-acetylgalactosa
Gene Name
CHSY1
Gene ID
22856
Swiss Prot
Q86X52
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, ELISA
Field of Research
Chondroitin sulfate biosynthesis
Purification
Affinity purification
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, ICC/IF 1:50-1:200, ELISA 1:5000-1:20000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
91kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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