HBO1 Rabbit Polyclonal Antibody
Product Specifications
Background
Catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone., domain:The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L., domain:The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction., function:Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the MYST (SAS/MOZ) family., similarity:Contains 1 C2HC-type zinc finger., subunit:Component of the HBO1 complex composed at least of ING4 or ING5, MYTS2/HBO1, EAF6, and one of PHF15, PHF16 and PHF17. Interacts with MCM2 and ORC1L. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone., tissue specificity:Ubiquitously expressed, with highest levels in testis., catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone., domain:The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L., domain:The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction., function:Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the MYST (SAS/MOZ) family., similarity:Contains 1 C2HC-type zinc finger., subunit:Component of the HBO1 complex composed at least of ING4 or ING5, MYTS2/HBO1, EAF6, and one of PHF15, PHF16 and PHF17. Interacts with MCM2 and ORC1L. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone., tissue specificity:Ubiquitously expressed, with highest levels in testis.
Product Name Alternative
KAT7; HBO1; HBOa; MYST2; Histone acetyltransferase KAT7; Histone acetyltransferase binding to ORC1; Lysine acetyltransferase 7; MOZ; YBF2/SAS3, SAS2 and TIP60 protein 2; MYST-2
Gene Name
KAT7
Gene ID
11143
Swiss Prot
O95251
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, ICC/IF, ELISA
Field of Research
Protein_Acetylation
Purification
Affinity purification
Dilution
WB 1:500-1:2000, ICC/IF 1:200-1:1000, ELISA 1:10000-1:20000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
75kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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