Gads Rabbit Polyclonal Antibody

This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014], function:Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc., similarity:Belongs to the GRB2/sem-5/DRK family., similarity:Contains 1 SH2 domain., similarity:Contains 2 SH3 domains., subunit:Interacts with phosphorylated LIME1 upon TCR activation (By similarity) . Interacts with phosphorylated LAT and LAX1 upon TCR activation. Interacts with SHB.

GRAP2; GADS; GRB2L; GRID; GRB2-related adapter protein 2; Adapter protein GRID; GRB-2-like protein; GRB2L; GRBLG; GRBX; Grf40 adapter protein; Grf-40; Growth factor receptor-binding protein; Hematopoietic cell-associated adapter protein Grp