CPE Rabbit Polyclonal Antibody

Carboxypeptidase E (CPE) Homo sapiens This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015], catalytic activity:Release of C-terminal arginine or lysine residues from polypeptides., cofactor:Binds 1 zinc ion per subunit., function:Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin., similarity:Belongs to the peptidase M14 family., subcellular location:Secretory granules of pancreatic islets, adrenal gland, pituitary and brain.