HSP90β (phospho Ser254) Rabbit Polyclonal Antibody

This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012], function:Molecular chaperone. Has ATPase activity., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the heat shock protein 90 family., subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV., subunit:Homodimer. Interacts with TP53/p53 (By similarity) . Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer.