AP-2γ Rabbit Polyclonal Antibody

Transcription factor AP-2 gamma (TFAP2C) Homo sapiens The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq, Jul 2008], domain:The WW-binding motif mediates interaction with WWOX., function:Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC., induction:During retinoic acid-mediated differentiation., online information:Activatin protein 2 entry, PTM:Sumoylated on Lys-10; which inhibits transcriptional activity., similarity:Belongs to the AP-2 family., subunit:Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity) . Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I.