AP-1 (phospho Ser63) Rabbit Polyclonal Antibody
Product Specifications
Background
This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008], function:Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'., PTM:Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC., similarity:Belongs to the bZIP family., similarity:Belongs to the bZIP family. Jun subfamily., similarity:Contains 1 bZIP domain., subunit:Heterodimer with either FOS or BATF3. Interacts with HIVEP3 (By similarity) . Interacts with SMAD3/SMAD4 heterodimers. Interacts with MYBBP1A, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA.
Product Name Alternative
JUN; Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39
Gene Name
JUN
Gene ID
3725
Swiss Prot
P05412
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, ELISA
Field of Research
MAPK_ERK_Growth; MAPK_G_Protein; ErbB_HER; WNT; WNT-T CELLFocal adhesion; Toll_Like; T_Cell_Receptor; B_Cell_Antigen; Neurotrophin; GnRH; Epithelial cell signaling in Helicobacter pylori infection; Pathways in cancer; Colorectal cancer; Renal cell carcinoma
Purification
Affinity purification
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, ICC/IF 1:50-1:200, ELISA 1:10000-1:20000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Phosphorylated
Molecular Weight
39-42kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Product Datasheet
https://assets.enkilife.com/files/antibody/APRab04235_Enkilife_EN.pdf
Isotype
IgG
Available Sizes
Curated Selection
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