IL-1β Rabbit Polyclonal Antibody

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE) . This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008], domain:The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function., function:Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells., online information:Interleukin-1 entry, online information:The Singapore human mutation and polymorphism database, similarity:Belongs to the IL-1 family., subcellular location:The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins., subunit:Monomer.

MAPK_ERK_Growth; MAPK_G_Protein; Cytokine-cytokine receptor interaction; Apoptosis_Inhibition; Apoptosis_Mitochondrial; Apoptosis_Overview; Toll_Like; NOD-like receptor; Cytosolic DNA-sensing pathway; Hematopoietic cell lineage; Type I diabetes mellitus; Alzheimer's disease; Prion diseases; Graft-versus-host disease