Cdk4 Rabbit Polyclonal Antibody

Cyclin dependent kinase 4 (CDK4) Homo sapiens The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16 (INK4a) . This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb) . Mutations in this gene as well as in its related proteins including D-type cyclins, p16 (INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008], catalytic activity:ATP + a protein = ADP + a phosphoprotein., disease:CDK4 mutations are involved in tumor formation., disease:Defects in CDK4 are the cause of cutaneous malignant melanoma 3 (CMM3) [MIM:609048, 155600]. Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a preexisting benign nevus, which occurs most often in the skin but also may involve other sites., enzyme regulation:Phosphorylation at Thr-172 is necessary for enzymatic activity., function:Probably involved in the control of the cell cycle., similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily., similarity:Contains 1 protein kinase domain., subunit:Forms a stable complex with D-type G1 cyclins. Interacts with SEI1 and ZNF655/VIK.

Cell_Cycle_G1S; Cell_Cycle_G2M_DNA; p53; Tight junction; T_Cell_Receptor; Pathways in cancer; Pancreatic cancer; Glioma; Melanoma; Bladder cancer; Chronic myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer