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ErbB 3 Rabbit Monoclonal Antibody

Product Specifications

Background

This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation.

Product Name Alternative

ERBB3; HER3; Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3

Gene Name

ErbB 3

Gene ID

2065

Swiss Prot

P21860

Host

Rabbit

Reactivity

Human

Clonality

Monoclonal

Conjugation

Unconjugated

Applications

WB

Purification

Affinity Purification

Dilution

WB 1:500-1:1000

Form

Liquid

Buffer

Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

Modification

Unmodified

Molecular Weight

Calculated MW: 148 kDa; Observed MW: 185 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Isotype

IgG

Available Sizes

Frequently Asked Questions

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