Phospho-AKT1 (Thr450) Rabbit Monoclonal Antibody
Product Specifications
Background
Akt, also referred to as PKB or Rac, plays a critical role in controlling survival and apoptosis. This protein kinase is activated by insulin and various growth and survival factors to function in a wortmannin-sensitive pathway involving PI3 kinase. Akt is activated by phospholipid binding and activation loop phosphorylation at Thr308 by PDK1 and by phosphorylation within the carboxy terminus at Ser473.
Product Name Alternative
AKT1; PKB; RAC; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha
Gene Name
Phospho-AKT1 (Thr450)
Gene ID
207
Swiss Prot
P31749
Host
Rabbit
Reactivity
Human, Rat
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, IP
Field of Research
Apoptosis, TGF-beta signaling pathway, PI3K-Akt signaling pathway, mTOR signaling pathway, MAPK signaling pathway, Jak-STAT signaling pathway
Purification
Affinity Purification
Dilution
WB 1:500-1:1000, IP 1:10-1:20
Form
Liquid
Buffer
Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.
Modification
Phosphorylated
Molecular Weight
Calculated MW: 56 kDa; Observed MW: 56 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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