CoREST Rabbit Monoclonal Antibody
Product Specifications
Background
Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval.
Product Name Alternative
COREST; Nr2b2; RCOR; Rcor1; Rxrb; ; REST corepressor 1
Gene Name
CoREST
Swiss Prot
Q9UKL0
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, ICC
Purification
Affinity Purification
Dilution
WB 1:1000-1:2000, IHC 1:100-1:200, ICC/IF 1:50-1:200, ICC 1:50-1:200
Form
Liquid
Buffer
Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.
Modification
Unmodified
Molecular Weight
Calculated MW: 53 kDa ; Observed MW: 66 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
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