Galectin-9 Rabbit Monoclonal Antibody

Binds galactosides (By similarity) . Has high affinity for the Forssman pentasaccharide (By similarity) . Ligand for HAVCR2/TIM3 (By similarity) . Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (By similarity) . Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (PubMed:20937702) . Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307) . Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (PubMed:25065622) .