Dnmt1 Rabbit Monoclonal Antibody
Product Specifications
Background
This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Product Name Alternative
AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; m.HsaI
Gene Name
Dnmt1
Gene ID
1786
Swiss Prot
P26358
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, FC
Purification
Affinity Purification
Dilution
WB 1:1000-1:5000, IHC 1:200-1:1000, ICC/IF 1:100-1:200, FC 1:20-1:50
Form
Liquid
Buffer
Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Modification
Unmodified
Molecular Weight
Calculated MW:183 kDa; Observed MW:183 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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