Phospho-Rb (Thr356) Rabbit Monoclonal Antibody

Product Specifications

Background

Cell cycle-dependent phosphorylation by a CDK inhibits Rb target binding and allows cell cycle progression. Rb inactivation and subsequent cell cycle progression likely requires an initial phosphorylation by cyclin D-CDK4/6 followed by cyclin E-CDK2 phosphorylation. Specificity of different CDK/cyclin complexes has been observed in vitro and cyclin D1 is required for Ser780 phosphorylation in vivo.

Product Name Alternative

RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110

Gene Name

Phospho-Rb (Thr356)

Gene ID

5925

Swiss Prot

P06400

Host

Rabbit

Reactivity

Human, Rat

Clonality

Monoclonal

Conjugation

Unconjugated

Applications

WB, IHC, IP

Purification

Affinity Purification

Dilution

WB 1:500-1:1000, IHC 1:50-1:100, IP 1:10-1:20

Form

Liquid

Buffer

Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

Modification

Phosphorylated

Molecular Weight

Calculated MW: 106 kDa; Observed MW: 110 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Isotype

IgG

Available Sizes

Curated Selection

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