RGMA Rabbit Monoclonal Antibody

Product Specifications

Background

Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition.

Product Name Alternative

Repulsive guidance molecule A; RGM; RGM domain family member A; RGMA; ; Repulsive guidance molecule A

Gene Name

RGMA

Swiss Prot

Q96B86

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Monoclonal

Conjugation

Unconjugated

Applications

WB, ICC

Purification

Affinity Purification

Dilution

WB 1:1000-1:2000, ICC 1:50-1:200

Form

Liquid

Buffer

Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

Modification

Unmodified

Molecular Weight

Calculated MW: 49 kDa ; Observed MW: 37 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Isotype

IgG

Available Sizes

Curated Selection

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