Phospho-MLKL (S345) Rabbit Monoclonal Antibody
Product Specifications
Background
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process.Does not have protein kinase activity.Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage.
Product Name Alternative
HMLKL ; Mixed lineage kinase domain like; Mixed lineage kinase domain like protein; Mixed lineage kinase domain like pseudokinase; ; p-Mlkl (S345)
Gene Name
Phospho-MLKL (S345)
Swiss Prot
Q9D2Y4 (mouse) Q8NB16 (Human)
Host
Rabbit
Reactivity
Mouse
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, IP
Purification
Affinity Purification
Dilution
WB 1:1000-1:2000, IP 1:20-1:50
Form
Liquid
Buffer
Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.
Modification
Phosphorylated
Molecular Weight
54 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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