PI3-Kinase p85 α Rabbit Monoclonal Antibody

Cell localization:nucleus, cytoplasm, cis-Golgi network, cytosol, plasma membrane, cell-cell junction, phosphatidylinositol 3-kinase complex, phosphatidylinositol 3-kinase complex, class IA, membrane, perinuclear endoplasmic reticμLum membrane, .Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regμLatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regμLatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insμLin, and a mutation in this gene has been associated with insμLin resistance. Alternative splicing of this gene resμLts in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]

PIK3R1; GRB1; Phosphatidylinositol 3-kinase regμLatory subunit alpha; PI3-kinase regμLatory subunit alpha; PI3K regμLatory subunit alpha; PtdIns-3-kinase regμLatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regμLatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regμLatory subunit p85-alpha